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Nature 485 , 661665 (2012)

This process, while effective for fat loss, may also begin breaking down muscle tissue for energy when the lack of calories is significant

This mechanism raises the critical discontinuation question - does stopping GHK-Cu immediately halt enhanced collagen production returning synthesis rates to pre-treatment baseline, or does the improved dermal environment created during treatment continue supporting elevated collagen production through positive feedback mechanisms where better matrix structure itself promotes ongoing synthesis even without continuous peptide stimulation

Combination therapy erases this gap while adding complexity and cost